Background: Benign prosatic hyperplasia(BPH) is a major health problem world wide many herbal and synthetic drugs are used to treat our intention is to investigation of different doses of stearic acid and palmitic acid on testosterone induced prostatic hyperplasia in rats. Method: Animals were divided into seven groups (n=6). Group- I received vehicle served as negative control, Groups-II to Group-VII treated with subcutaneous testosterone (3 mg kg-1) injection for 14 days to induce prostatic hyperplasia(PH). Among six, one group served as positive control, and remaining 5 groups treated with low dose of steric acid (SA1) and, high dose of steric acid (SA2); low dose of palmitic acid (PA1), high dose of palmitic acid (PA2) and Finasteride (FT) groups. All drugs treatment given orally for period of 14 days. Rats were weighed before initiation and after completion of an experiment. Rats were sacrificed under light ether anaesthesia and isolated prostates were weighed and their Histopathological studies were carried out. Results: There was no change in body weight of rats before and after treatment. Both doses of steric acid and palmitic acid have significantly inhibited the elevation in prostate weight (PW) and PW to body weight (BW) ratio. As expected finasteride inhibited the elevation in prostate weight (PW) and PW to body weight (BW). Histopathological finding finasteride and both doses steric acid and palmitic acid showed protective effect against testosterone induced prostate cell growth. Conclusion: All doses of steric acid and palmitic acid showed protective against on testosterone induced prostatic hyperplasia in rats
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